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运放调零

请问,在电路设计中,运算放大器都存在输入失调电压,导致在输入为零的情况下输出不为零,但是在一些应用中我关心的是输入变化的情况下输出电压的电压差,而不是其绝对值,那我还是不是必须要把运放调零呢?