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关于TM4C123gh6pz的AD采样问题

单片机采样3V电压,但3V的电压地GND不是单片机的供电地,3V和单片机供电也是隔离的,我是不是需要修改vrefa+和vrefa-,变为和采样的电压和地一样的基准?是否需要修改其他的?